Saint James Intercisus, also known as Saint James the Mutilated (died 421) was a Persian saint.

Tradition states that he was a military officer and courtier to Yazdegerd I who had apostatized after this ruler began to persecute Christians.

 Under the influence of his Christian family, however, he expressed his faith to Yazdegerd's successor, Bahram V, and was tortured and killed.

His death started the Roman-Sassanid War (421-422). He was killed in Gundishapur. The ruins of this city are near Dezful, Iran.