Hormizd II was the eighth king of the Sasanian Empire, and reigned for seven years and five months, from 302 to 309. He was the son of Narseh (293–302).

In 302, Hormizd II ascended the throne, assuming a crown resembling the crown used by the early Sasanian rulers. Hormizd II, unlike his father, persecuted the Manicheans who had lived peacefully during the reign of his father.

 Hormizd tried to improve Sasanian relations with Armenia, which had recently under Tiridates III of Armenia declared Christianity as its state religion; he gave his daughter Hormizddukht in marriage to a Mamikonian prince named Vahan.

In 309, while Hormizd was hunting, he was wounded by a Ghassanid army, and was shortly killed by the Sasanian nobles.