Siroe, re di Persia (Siroes, King of Persia), is an opera seria in three acts by George Frideric Handel.

It was his 12th opera for the Royal Academy of Music and was written for the sopranos Francesca Cuzzoni and Faustina Bordoni.

The opera uses an Italian-language libretto by Nicola Francesco Haym, after Metastasio's Siroe.

Like many of Metastasio's libretti, it was also set by Handel's contemporaries, e.g. by Leonardo Vinci, Antonio Vivaldi and Johann Adolph Hasse.

Pasquale Errichelli's setting of the libretto premiered in the year of Handel's death.

The story of the opera is a fictionalisation of some events in the life of Kavad II, King of the Sasanian Empire in 628 AD.