The speech was interesting in many ways, including his tough line on the Saudis and their allies not doing enough to confront their extremists, urging them to drive the extremists out. But the most consequential part of it may be his line that Iran must be isolated until it has a different regime that deals with the world differently. Just when Iranians voted overwhelmingly for openness and engagement with world, Trump clenched his fist and responded by calling for Iran's isolation.